Endocrine Abstracts

Background: Ectopic pituitary adenomas are defined by the presence of adenomatous pituitary tissue outside the sella and distinctly separate from the pituitary gland. Ectopic ACTH-secreting pituitary adenomas (EAPAs) are a rare cause of Cushing’s syndrome. Detecting these radiologically can prove difficult, in part, due to their typically small size and unpredictable anatomical location.Aim: We reviewed the current literature on all previously repor...

Background: Successful pituitary surgery in patients with Cushing disease (CD) can result in long term remission and sustained weight loss. We examined rates of body weight changes in the post-operative period (within 6 months) in patients with active CD who underwent transsphenoidal surgery (TSS) and the relationship of weight loss to remission status.Methods: Clinical data was obtained from a CD database in addition to an online patient medical record ...

Background: Most cases of Cushing’s disease originate from the pituitary, rarely the source of excess ACTH is from an ectopic pituitary adenoma.Case: A 34-year-old woman had a 12-month history of a labile mood, weight gain, easy bruising, irregular menses and hypertension, she appeared cushingoid. Biochemical investigations demonstrated hypercortisolism: 24 h urine-free cortisol 520.7 μg (4–50), ACTH 152 pg/ml (8–42); midnight salivar...